The final cut?

Cytokinesis: Placing and Making the Final Cut

Cytokinesis is the process by which cells physically separate after the duplication and spatial segregation of the genetic material. A number of general principles apply to this process. First the microtubule cytoskeleton plays an important role in the choice and positioning of the division site. Once the site is chosen, the local assembly of the actomyosin contractile ring remodels the plasma ...

Notch Cleavage: Nicastrin Helps Presenilin Make the Final Cut

Presenilin is thought to be the proteolytic component of gamma-secretase, responsible for the intramembranous cleavage of substrates that include the activated Notch receptor. Recent studies have identified the novel protein Nicastrin as another essential component of the Presenilin/gamma-secretase complex.

New players to the field of ADP-ribosylation make the final cut.

ADP-ribose-based intermediates, including PARP-generated monoand poly(ADP-ribose) post-translational modifications, are important to a number of cellular signalling processes. The reversal of poly(ADP-ribosyl)ation is mostly attributed to PARG, which however cannot remove the final protein-linked mono(ADP-ribose) residue. Three recent studies, one of them in The EMBO Journal, now report that ce...

Making the Final Cut – The Role of Endosomes During Mitotic Cell Division

DIP: Final project report Image segmentation based on the normalized cut framework

Yu-Ning Liu Chung-Han Huang Wei-Lun Chao R98942125 R98942117 R98942073 Motivation Image segmentation is an important image processing, and it seems everywhere if we want to analyze what inside the image. For example, if we seek to find if there is a chair or person inside an indoor image, we may need image segmentation to separate objects and analyze each object individually to check what it is...